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KMID : 1145520170030010025
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Journal of Radiopharmaceuticals and Molecular Probes
2017 Volume.3 No. 1 p.25 ~ p.31
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Gamma camera/MR dual imaging liposome labeled with radioisotope and paramagnetic ions
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Kim Youn-Ji
Kim Jong-Hee
Lee Woong-Hee
Yoo Jeong-Soo
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Abstract
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Liposomes are defined as spherical, self-closed structures formed by lipid bilayers containing aqueous phase. Most liposomes are composed of various amphipathic lipids such as phospholipids and cholesterol. We used amphipathic lipids (DPPC, DPPG) as liposome components and prepared around 100 nm liposomes by standard extrusion method. Nuclear/MR dual imaging agents based on liposome platform were prepared by adding radioactive 131I-HIB (hexadecyl-4-tributylstannylbenzoate) and Gd-DTPA into liposome bilayer and inside liposome, respectively. Gamma camera and MR imaging both showed signal increases in liver.
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KEYWORD
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liposome, radioactive liposome, dual imaging, Gamma camera, MR imaging
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